远隔缺血后处理对脑保护作用机制的研究进展

摘要

Remote ischemic postconditioning can significantly reduce the cerebral ischemia /reperfusion injury .By kinds of mechanisms such as reducing oxidative stress damage ,triggerring autophagy ,inhibitting apoptosis ,activation of signa-ling pathways or open an ion channel , NO relevant way , realizing cranial nerve protective effect .In my paper , the specific mechanism of the system were reviewed .%缺血性脑卒中是一种具有高致残率、高致死率和高复发率的疾病。虽然目前血管内介入技术及溶栓药物的应用可有效缓解多数患者的临床症状，实现很好的临床转归，但其带来的缺血再灌注损伤也不容忽视，研究者们经过不懈努力，最终发现缺血后处理，尤其是远隔缺血后处理能够显著减轻脑缺血／再灌注损伤，通过减轻氧化应激损伤、触发自我吞噬、抑制细胞凋亡、激活信号通路或开放离子通道途径、调控NO相关途径等机制实现脑神经保护作用，本文就上述具体机制进行系统综述。