有2型糖尿病家族史的非肥胖青少年血浆Ghrelin水平变化的影响因素

摘要

Objective To investigate the influencing factors of ghrelin in non-obese adolescents with family history of type 2 diabetes. Methods The study included 80 non-obese adolescents aged 13-15 years. 40 subjects had no family history of type 2 diabetes (FHD- group), and 40 subjects had a family history of type 2 diabetes (FHD+ group). Body height, weight and blood pressure were measured. Fasting plasma glucose(FPG) , serum lipids, fasting true insulin (FTI) and ghrelin were assayed. Results FHD+ group had significantly higher levels of body mass index(BMI) ,FPG,FTI and HOMA-IR than did FHD~ group (P<0. 05). FHD+ group had significantly lower level of ghrelin than did FHD- group (P< 0. 01). Ghrelin showed negative correlation with FPG(r = -0. 456,P=0. 000) ,FTI(r = -0.183,P= 0.021) and HOMA-IR (r = - 0. 237, P = 0. 003) . In multiple linear regression analysis, FPG (β= -354.435, P= 0.000) and FHD(β= - 176. 468, P = 0.006) were significantly independent relative foctors for ghrelin. Conclusions The lower ghrelin level is found in non-obese adolescents with family history of type 2 diabetes. Elevated FPG and FHD may be the relative factors for lower ghrelin level.%目的 探讨有T2DM家族史且BMI正常的青少年空腹血浆中Ghrelin水平的变化及相关影响因素.方法 80名13～15岁BMI正常青少年,根据有无糖尿病家族史分为糖尿病家族史阳性组(FHD+)和糖尿病家族史阴性组(FHD-).测量身高、体重及血压,检测FPG、血脂、空腹真胰岛素(FTI)及Ghrelin水平.结果 FHD+组BMI、FPG、FTI和胰岛素抵抗指数(HOMA-IR)高于FHD-组(P＜0.05),空腹Ghrelin水平低于FHD-组(P＜0.01).Ghrelin与FPG(r=-0.456,P＜0.01),FTI(r=-0.183,P＜0.05)和HOMA-IR(r=-0.237,P＜0.01)呈负相关.以Ghrelin为因变量,行多元线性回归显示,FPG(β=-354.435,P＜0.01)和FHD(β=-176.468,P＜0.01)为独立危险因素.结论 有T2DM家族史的BMI正常的青少年已存在空腹Ghrelin水平的降低,FPG的升高和糖尿病家族史可能是Ghrelin水平降低的相关因素.