代谢综合征与非代谢综合征人群不同血脂成分对2型糖尿病发病风险的影响

摘要

目的 通过前瞻性研究比较non-HDL-C、LDL-C在代谢综合征(MS)人群、非MS人群中与2型糖尿病(T2DM)发病的关系.方法 将各血脂指标按水平三等分,以不患MS且血脂水平处于第一等分组的人群为对照组,比较MS、非MS人群各血脂水平与T2DM发病的关系.结果 MS人群的血脂水平明显高于非MS人群.非MS人群中,TG、non-HDL-C、LDL-C水平在第三等分组时发生T2DM的风险最高.MS人群发生T2DM的风险均高于同血脂水平的非MS人群,但第三等分组发生T2DM的相对危险度(RR值)并没有增加.结论 MS人群发生T2DM的风险高于非MS人群,但其发生T2DM的风险并没有随血脂水平的增高而增加.而非MS人群中,non-HDL-C、LDL-C在第三等分组发生T2DM的风险最高,且non-HDL-C的预测作用强于LDL-C.%Objective The effects of the different blood lipid components on the T2DM occurrence in metabolic syndrome (MS) versus non-MS patients. Methods The risk ratio (RR) of type 2 diabetes occurrence was assessed based on different blood lipid componet effects in MS versus non-MS patients.Results Patients with MS had a higher T2DM RR than those without MS. In a multivariate model,T2DM risk in MS population didn't increase with increasing lipid. While in non-MS population, the third trisection of non-HDL-C, LDL-C had the highest RRs of 1.69[1.06-2. 68] in non-HDL-C of the third trisection, and 1.64[1.02-2. 63]in LDL-C of the third trisection (all P＜0. 05). Conclusions Non-HDL is a stronger predictor for T2DM occurrence among the non-MS population than LDL, and it should be given more consideration in the clinical approach to risk reduction among non-MS populations.