在T2DM的发生发展过程中,胰岛α细胞和β细胞存在结构和数量异常、功能障碍.胰升血糖素样肽-1(GLP-1)类似物利拉鲁肽可直接改善胰岛β细胞功能、抑制其凋亡和增加其数量,并能作用于胰岛α细胞,不仅能够调节细胞功能,早期应用于T2DM治疗有效改善血糖,减少低血糖发生率,还能带来降低体重、SBP的益处,其具有药物经济学优势,是T2DM早期治疗的理想选择.%During the development of type 2 diabetes, there appear anomalies of islet β-and orcell function, structure and amount GLP-1 analogue liraglutide can improve β-cell function, decrease β-cell apoptosis, increase β-cell mass, and also regulate or cell function. For type 2 diabetes treatment, early usage of liraglutide provides better glucose control, lower incidence of hypoglycemia, and more benefits of weight loss, systolic blood pressure reduction, as well as the pharmacoeconomic advantages. Liraglutide is an ideal choice for type 2 diabetes early treatment.
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