T2DM患者的合理膳食、食物,以及天然产物中降血糖和提高胰岛素敏感性功能成分是一热门研究领域.一项体外研究结果发现,咖啡成分可抑制人胰岛淀粉样多肽形成,饮用咖啡和糖尿病之间可能存在联系.关于饮用咖啡对T2DM影响的研究结果很不一致.而我国目前尚无上述两种关系的流行病学及随机对照干预试验的研究数据,加之我国居民饮用咖啡的历史较短,饮用量较西方国家低得多,日饮3杯以上咖啡的人群可能屈指可数,而我国居民机体对咖啡的应答是否同于西方人至今不明.此外,还应考虑咖啡因对睡眠和血压的急性影响等不良反应.鉴于此,为了防治T2DM而每日饮用3杯以上咖啡至少目前缺乏令人信服的科学依据.%It is a hot research area whether an appropriate diet and the functional components of food and natural products can lower blood glucose and improve insulin sensitivity in type 2 diabetes. An in vitro study found that some ingredients of coffee could inhibit amyloid polypeptide formation of human pancreatic islet Therefore, the authors suggested a possible link between coffee consumption and diabetes prevention. However, the findings of inhibition of type 2 diabetes by coffee drinking were controversy. In addition, there is no data of epidemiology and randomized controlled trial studies supporting the relationship between drinking coffee and type 2 diabetes mellitus in China. Moreover, the history of drinking coffee is shorter and the amount of coffee consumption is much lower in China than those in Western countries. Our population may be only a handful of people drinking three or more cups of coffee everyday. It is still unknown whether our residents have a same response to coffee as Western populations. Furthermore, the acute effects of caffeine on sleep and blood pressure and other side effects should also be taken into consideration. In view of this, the daily consumption of more than three cups of coffee for the prevention of type 2 diabetes, at least now,is in lack of convincing scientific basis.
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