12-羟基二十碳四烯酸与2型糖尿病合并冠心病的相关分析

摘要

目的 探讨12-羟基二十碳四烯酸(12 HETE)在T2DM合并冠心病(CHD)中的作用.方法 测定109例T2DM非CHD患者(T2DM)组,152例T2DM合并CHD患者(CHD)组和103名健康对照者(NC)组的12-HETE水平. 结果 T2DM组和CHD组的12-HETE水平高于NC组(P＜0.01),且CHD组高于T2DM组(P＜0.01).T2DM组和CHD组的12-HETE均与Gensini积分相关(r=0.430,P=0.001;r=0.371,P=0.001). 结论 12-HETE可能与糖尿病合并CHD的发生有关.%Objective To study the relationship between 12-Hydroxyeicosatetraenoic acid (12-HETE) and coronary heart disease (CHD) in T2DM patients. Methods The level of 12-HETE was detected in 109 cases of T2DM without CHD, 152 cases of T2DM with CHD, and 103 healthy adults. Results The level of 12-HETE was higher in T2DM and CHD groups than in the control group (P< 0. 01), and it was higher in CHD group than in T2DM group (P<0.01). The level of 12-HETE was correlated with Gensini score in both groups (r=0. 430, P=0. 001; r=0. 371, P=0. 001). Conclusion 12-HETE plays a role in the development of CHD in T2DM patients.