尿微量白蛋白与2型糖尿病患者颈动脉内中膜厚度的相关性研究

摘要

目的 探讨T2DM患者尿微量白蛋白与颈动脉内膜中层厚度(IMT)的相关性.方法 微量白蛋白尿组(MAU)60例、30名健康者(NC)和30例正常白蛋白尿组(NMAU)作对照,测定血糖、UAER、血压及血肌酐等.采用彩色多普勒超声观察双侧颈动脉内膜中层厚度.结果 NMAU组较NC组FPG、IMT、SBP 明显升高(P<0.05)MAU组较NC组FPG、SBP、UAER、IMT也明显升高(P<0.05);MAU组较NMAU组IMT、UAER显著升高(P<0.01).MAU组患者UAER与IMT呈显著正相关(P<0.05).结论 MAU与颈动脉硬化密切相关,MAU可能为大血管及微血管病变的标志物.%Objective To explore the relationship between microalbuminuria and carotid intima-media thickness in type 2 diabetic patients. Methods Sixty microalbuminuria patients(MAU,UAER20-200 μg/min), 30 nonmicroalbuminuria patients(NMAU, UAER<20 μg/min) and 30 healthy people(NC) were selected in the reserch. The levels of glucose , UAER, blood-pressure and serum creatinine were measured. IMT of carotid arteries were determined with high-sensitive B-mode ultrasound. Results The levels of glucose, IMT,SBP were significantly increased in NMAU versus NC group(all P<0. 05). The levels of glucose, SBP, UAER and IMT were increased significantly in MAU versus NC group (all P< 0. 05). The levels of IMT and UAER were increased in MAU than in NMAU group(P<0. 05). UAER was negatively correlated with IMT. Conclusions Microalbuminuria is negatively correlated with IMT. Microalbuminuria level is likely to be a marker of diabetes' complications.