目的 研究正常人群中血清促甲状腺激素(TSH)与脂肪代谢的关系. 方法 对武汉市1322名正常人群进行体格检查、血清TSH测定及肝脏超声检查. 结果 超重(A)组血清TSH水平高于对照(B)组.女性TSH＞2.5 mI U/L(B)组体重、BMI、WC、体脂含量高于TSH≤2.5mI U/L(A)组.体脂含量、BMI是TSH的独立影响因素.TSH不是影响非酒精性脂肪肝患病的独立危险因素. 结论 女性正常范围内的血清TSH与肥胖密切相关；血清TSH与非酒精性脂肪肝的患病风险无关.%Objective To explore the relationship between serum TSH level and lipid metabolism in euthyroid subjects. Methods The 1322 subjects were enrolled in the trial. Physical, laboratory, and liver ultrasonography examinations were carried out for all of them. Results Serum TSH level was significantly higher in overweight (A)group than in control (B)group. Levels of body weight, BMI, waist circumference, and percentage of body fat were increased in TSH > 2. 5 ml U/L women (B) group compared with those in TSH<2. 5 ml U/L women (A)group. Percentage of body fat and BMI contributed significantly to the variance of TSH. TSH level was not the independent risk factor of non-alcoholic fatty liver disease. Conclusion Serum TSH in normal range is significantly correlated with obesity in women. And the change of TSH will not increase the prevalence of non-alcoholic fatty liver disease.
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