Ⅱ型糖尿病伴牙周炎病人牙龈组织中VEGF表达及MVD计数的研究

摘要

目的:探讨Ⅱ型糖尿病伴牙周炎病人牙龈组织中血管内皮生长因子(VEGF)的表达水平及其作用.方法:选取Ⅱ型糖尿病伴重度牙周炎(DP)病人、单纯重度慢性牙周炎(CP)病人、健康对照者(N)各15例,分别切取牙龈组织,用免疫组化染色方法检测牙龈组织中VEGF表达和MVD计数.结果:DP组牙龈组织中VEGF表达和MVD计数均显著高于CP组和N组(P ＜0.05);CP组高于N组(P＜0.05).结论:Ⅱ型糖尿病伴重度慢性牙周炎病人牙龈组织中VEGF表达水平和MVD计数明显升高.%AIM; To investigate vascular endothelial growth factor ( VEGF) expression level and microvessles density (MVD) count in gingival tissues of patients with type 2 diabetes mellitus and periodontitis, and to study the role of VEGF in the disease. METHODS: Patients with type 2 diabetes mellitus and severe chronic periodontitis ( group DP, n =15), patients with severe chronic periodontitis (group CP, n = 15), and healthy controls without periodontal and systemic disease (group N, n = 15) were included. Immunohistochemistry was used to detect the expression of VEGF and MVD count in gingival tissues of each group. RESULTS: VEGF expression and MVD count in DP group were significantly higher than those in CP and N groups (P<0.05). Furthermore, the parameters were significantly higher in CP group than in N group (P <0.05). CONCLUSION; VEGF expression level and MVD count were significantly increased in gingival tissues of type 2 diabetes mellitus with severe chronic periodontitis patient , indicating that VEGF might be used as an indicator for predicting periodontitis severity.