中、美、日三国啮齿类饲料样品比较分析——24个月长期啮齿类致癌性实验的饲料选择

摘要

目的 评估饲料品质、供应风险及价格,为24个月长期致癌性试验寻找最佳的饲料及饲料供应商.方法 将日本进口MF18饲料,美国进口LabDiet饲料以及北京科澳生产的啮齿类饲料样品分别包装,委托专业检测实验室对常规营养成分、毒理及微生物指标进行检测,评估饲料品质;对各来源饲料的运输风险、非可控因素等可能影响饲料品质及稳定供应的方面进行评估;兼顾饲料价格作为参考评估因素.结果 经评估,3种饲料品质均符合饲料国标GB14924-2001*的要求;以毒性研究关注的毒理指标作为评价标准,则3种饲料品质排序为:MF18饲料(最佳)-> LabDiet饲料(较佳)->科澳国产饲料(佳);进口饲料的运输及供应稳定性相比存在较大风险;国产饲料价格相对便宜但未成为关键评估因素.结论 经过综合评估,特殊定制的本地国产饲料被认定为是国家药物安全评价监测中心24个月致癌性试验用的最佳饲料.%Objective To find the best feed and feed supplier for 24-month rodent carcinogenicity studies by assessing the quality, supply risks and price of three rodent feeds. Methods Samples of the MF18 feed (Japan) , LabDiet ? feed (USA) and SPF domestic rodent feed (Beijing) were sent to a professional laboratory for testing the conventional nutrients, metals and pesticides, and microbiological indicators, and to evaluate the quality of the feeds. Risks on feed transport and non-controllable factors which might affect feed quality and supply were evaluated. The price of each feed as a reference factor was also considered. Results The quality of the three feeds met the requirements of standard GB14924-2001. According to the evaluation criteria for general toxicological indicators concerned in toxicity studies , the quality sort of the three feed was ranked as: MF18 feed (the best) -> LabDiet feed ( better) -> local feed produced in Beijing ( good) . There were signifieant risks in transportation and supply for the imported feeds. The priee of the domestie feed was relatively eheap but was not eonsidered as a eritieal faetor. Conclusions After a eomprehensive eomparison, the speeial eustomized domestie feed is seleeted for the 24-month eareinogenieity study to be eondueted in the National Centre for Safety Evaluation of Drugs.