目的：在猪房间隔缺损动物模型上评价改良的封堵器有效性、安全性和相容性。方法选用西藏小型猪5头，利用房间隔穿刺结合囊扩张的方法建立房间隔缺损（ atrial spetal defect， ASD）猪，用改良的封堵器进行房间隔封堵术，术后进行超声心动图、大体解剖、电镜扫描和光镜观察。结果5只猪均成功建立了ASD模型并进行封堵术成功，超声心动图观察显示封堵器良好，位置固定，心腔和心肺功能正常。3个月后封堵器与房间隔组织紧密嵌合，表面覆盖一层较厚的光滑的白色组织，电镜下观察到大量心肌纤维，未发现内皮细胞。结论改良的ASD封堵器操作简便、安全性好，具有良好的生物相容性。%Objective To evaluate the efficacy, safety and compatibility of a new type of atrial septal defect ( ASD) occluder in atrial spetal defect mini-pigs model.Methods Five Tibet mini-pigs were selected as the ASD models which were established by the combination of atrial septal puncture and balloon dilation.Then the new type occluder was implanted for the therapy of ASD.Transthoracic echocardiography with color Doppler was used in all animals during closure and in follow up examinations.The animals were killed at 3 months after occlusion for electron microscopical observation and microscopic examination.Result The ASD models had been created in five piglets successfully without complication, all of whom were implanted successfully with the new device without shunts.Postmortem and microscopic examination of the 5 specimens 3 months after placement showed complete.Conclusion Transcatheter ASD occlusion with new type ASD occluder is safe,feasible and effective.This occlusion can repair the atrial septal defect successfully.
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