先天性白内障Rncat小鼠行为学检测与分析

摘要

Objective To measure and analyze the behavioral changes of Rncat congenital cataract mice. Methods Normal BALB/c mice and KM mice were used as control group,and inbred and random mated Rncat congenital cataract mice were used as experimental group. Behavioral tests, including the open field test, coat-hanger test, forced swimming test,and tail suspension test,were conducted on the mice. Results Compared with the inbred Rncat congenital cataract mice,the residence time in the open field test,the immobility time in the forced swimming test and tail suspension test of the BALB/c mice, randomly-mated Rncat congenital cataract mice and KM mice were significantly different. Conclusions There are certain differences in behavioral performance between the Rncat congenital cataract mice and the other mice. Our findings may provide a useful reference for future researchers.%目的 对先天性白内障Rncat小鼠行为学变化进行检测与分析.方法 以正常的 BALB/c小鼠和KM小鼠为对照组,以近亲交配和随机交配的先天性白内障 Rncat小鼠为实验组,分别进行小鼠的行为学检测(旷场实验、衣架实验、强迫游泳实验、悬尾实验).结果 与近亲交配的 Rncat先天性白内障小鼠相比,BALB/c小鼠、随机交配的先天性白内障Rncat小鼠、KM小鼠的旷场实验停留时间、强迫游泳和悬尾实验的不动时间差异有显著性.结论 先天性白内障Rncat小鼠与其他小鼠相比行为学检测结果有一定差异,可为实验人员提供参考.