恶性肿瘤的治疗已进入“精准治疗”时代,抗肿瘤血管生成的靶向治疗是近年非常热门的研究方向,而肿瘤免疫逃逸是导致肿瘤治疗效果不理想的重要原因之一。抗血管生成治疗不仅能够抑制血管生成,使肿瘤退缩,并且能够减少肿瘤微环境中免疫抑制性细胞数量,提高肿瘤浸润淋巴细胞(tumor-infiltrating lymphocyte,TIL)、细胞毒性淋巴细胞(cytotoxic lymphocyte,CTL)等的数量,从而克服肿瘤免疫逃逸。本研究对抗血管生成药物通过改善肿瘤微环境,增强机体抗肿瘤免疫功能进行综述。%Malignant tumor therapy has entered a new era of"precise treatment."Nowadays, targeted anti-angiogenic agents have become a popular research topic that continues to attract increasing interest. Tumor immune escape plays an indispensable role in therapeutic resistance. Anti-angiogenic therapies not only prevent the tumor angiogenesis and suppress tumor growth but also neu-tralize tumor escape from a host's immune system by reducing the immunosuppressive cells and increasing the number of tumor-infil-trating lymphocyte (TIL) and cytotoxic lymphocte (CTL). This paper aims to review the mechanism underlying the manner by which an-ti-angiogenesis enhances immunity by influencing tumor microenvironment.
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