高压氧联合盐酸多奈哌齐治疗卒中后认知功能障碍

摘要

目的：分析高压氧联合盐酸多奈哌齐对卒中后认知功能障碍的疗效。方法：将90例住院治疗的卒中后认知功能障碍患者分为高压氧联合盐酸多奈哌齐10 mg组、盐酸多奈哌齐10 mg组、盐酸多奈哌齐5 mg组，每组各30例。采用简易精神状态量表（MMSE）及日常生活能力量表（ADL）评价3组患者治疗前后的认知功能。结果：高压氧联合盐酸多奈哌齐10 mg组患者治疗后MMSE和ADL评分较单用盐酸多奈哌齐组明显增加，差异有统计学意义（P＜0．01）。结论：高压氧联合盐酸多奈哌齐（10 mg ）对卒中后伴认知功能障碍患者的疗效较好。%Objective:To analyze the efficacy of hyperbaric oxygen combined with donepezil hydrochloride on post‐stroke cogni‐tive impairment .Methods:Ninety hospitalized patients with post‐stroke cognitive impairment were selected .They were divided into hyperbaric oxygen combined with donepezil hydrochloride 10 mg group ,donepezil hydrochloride 10 mg group and donepezil hydrochloride 5 mg group ,with 30 cases in each group .Cognitive functions in 3 groups before and after the treatment were e‐valuated with the mini mental state examination (MMSE) and the ability of daily living scale (ADL) .Results:The scores of MMSE and ADL of patients in hyperbaric oxygen combined with donepezil hydrochloride 10 mg group increased more than those in donepezil hydrochloride groups after treatment ,and the differences were statistically significant (P<0 .01) .Conclu‐sions:Hyperbaric oxygen combined with donepezil hydrochloride 10 mg shows superior efficacy on post‐stroke patients accom‐panied by cognitive impairment .