吸烟与非吸烟慢性阻塞性肺疾病患者血清CC-16的表达水平

摘要

目的：探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease ，COPD）患者中吸烟人群和不吸烟人群血清Clara细胞蛋白（Clara cell protein ，CC‐16）的表达水平。方法：入选COPD稳定期患者，记录入选者的基本情况、临床症状及肺功能等资料，并留取血清，采用ELISA法检测CC‐16水平。按照是否有吸烟史将患者分为吸烟COPD和非吸烟COPD ，以吸烟和非吸烟的健康体检者为对照。结果：共入选COPD患者34例，吸烟组17例，非吸烟组17例；健康人吸烟组15例，健康人非吸烟对照组19例。吸烟COPD组男性比例高于非吸烟COPD组，差异有统计学意义（P＜0．05）。吸烟和非吸烟COPD患者年龄、肺功能差异无统计学意义。与健康对照组相比，COPD患者血清CC‐16水平降低（P＜0．001）。吸烟和非吸烟COPD患者血清CC‐16水平差异无统计学意义；与非吸烟健康者相比，吸烟健康者血清CC‐16呈现下降趋势，但差异无统计学意义。结论：COPD患者血清CC‐16表达水平低于健康体检者，但吸烟与不吸烟COPD患者血清CC‐16表达无明显差异，相关结论有待大样本研究证实。%Objective:To observe the serum levels of Clara cell protein (CC‐16) in non‐smoking and smoking patients with chronic obstructive pulmonary disease (COPD) .Methods:The basic information ,clinical symptoms and lung functions of patients were collected ,the serum was used to measure the CC‐16 levels by ELISA .The patients were divided into stable COPD and non‐COPD based on smoking history ,and compare with the healthy cases with or without smoking history .Results:Totally 34 cases were selected ,including 17 smoking COPD ,and 17 non‐smoking COPD .15 smoking non‐COPD and 19 non‐smoking non‐COPD healthy cases were selected .The male patients in smoking COPD group were more than which in non‐smoking COPD group (P<0 .05) ,but no statistical significance of age and lung functions in smoking COPD group and non‐smoking COPD group .The level of serum CC‐16 was significantly decreased in COPD patients (P< 0 .001) .There was no statistical significance of serum CC‐16 found between COPD patients with or without smoking history .The level of serum CC‐16 was tending to decrease in non‐COPD smokers ,but there was no statistical significance .Conclusions:The level of serum CC‐16 is lower in COPD patients than that in healthy controls .There is no statistical significance in serum CC‐16 between smoking COPD patients and non‐smoking COPD patients ,which is need more evidences from further study on larger population .