A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with (Hetero)aryl Chlorides

摘要

((2S,4R)-4-Hydroxy-N-(2-methylnaphthalen-1-yl)pyrrolidine-2-carboxamide (HMNPC),an amide derived from 4-hydroxy-L-proline and 2-methyl naphthalen-l-amine,is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts,allowing for first time the metal-catalyzed coupling of (hetero)aryl chlorides and NaSO2Me.A considerable number of (hetero)aryl chlorides worked well,providing the pharmaceutically important (hetero)aryl methylsulfones in good to excellent yields.