Objective: To investigate clinical value detecting glycosylated hemoglobin (HbAlc) and C- reactive protein (CRP) in patients with gestational diabetes mellitus (GDM). Methods: A total of 179 GDM patients were enrolled as GDM group, 157 non-diabetic pregnant women were enrolled as no-diabetes pregnant women (NDG) group and another 164 healthy subjects were regard as healthy control group. High performance liquid chromatogra-phy was used to measure HbAlc level and Hitachi type 7170 automatic biochemical analyzer was used to measure CRP level, and the results were compared among three groups. Results: Compared with healthy control group and NDG group, there were significant increase in levels of HbAlc [ (4.97 ± 0. 25) % , (5. 64 ± 0. 85)% vs. (10. 08 ± 1.05)%]and CRP[<2.42±0.78) mg/L, (4.96±0. 65) mg/L vs. (10.2510. 87) mg/L] in GDM group, P<0. 05 all; Pearson rectilinear correlation analysis indicated that CRP level was significant positively correlated with fasting blood glucose (r = 0. 493, P<0. 05). Conclusion: Detecting glycosylated hemoglobin and C - reactive protein possesses important value for diagnosis of gestational diabetes mellitus.%目的:探讨在妊娠期糖尿病患者检测糖化血红蛋白(HbA1c)和C反应蛋白(CRP)的价值.方法:人选妊娠期糖尿病患者179例(GDM组),非糖尿病孕妇157例(NDG组)和健康体检者164例(健康对照组),采用高效液相色谱法检测HbA1c水平,日立7170型全自动生化分析仪检测CRP水平,并进行比较.结果:与健康对照组和NDG组比较,GDM组HbAlc [(4.97±0.25)％、(5.64±0.85)％比(10.08±1.05)％]和CRP[(2.42±0.78) mg/L、(4.96±0.65) mg/L比(10.25±0.87) mg/L]水平明显升高(P均＜0.05); Pearson直线相关分析显示,CRP水平与空腹血糖呈明显正相关(r=0.493,P＜0.05).结论:检测糖化血红蛋白和C反应蛋白对妊娠期糖尿病患者的诊断具有重要价值.
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