二维半导体探测器阵列的方向性响应和在调强放射治疗合成剂量验证中的应用研究(英文)

摘要

Background and Objective:The planning dose distribution of intensity-modulated radiation therapy(IMRT) has to be verified before clinical implementation.The commonly used verification method is to measure the beam fluency at 0 degree(0°) gantry angle with a 2-dimensional(2D) detector array,but not the composite dose distribution of the real delivery in the planned gantry angles.This study was to investigate the angular dependence of a 2D diode array(2D array) and the feasibility of using it to verify the composite dose distribution of IMRT.Methods:Angular response of the central detector in the 2D array was measured for 6 MV X-ray,10 cm × 10 cm field and 100 cm source axis distance(SAD) in different depths.With the beam incidence angle of 0°-60°,at intervals of 10°,and inherent buildup of the 2D array(2 g/cm2),the array was irradiated and the readings of the central diode were compared with the measurement of thimble ionization chamber.Using a combined 30 cm × 30 cm × 30 cm phantom which consisted of solid water slabs on top and underlying the 2D array,with the diode detectors placed at 8 g/cm2 depth,measurements were taken for beam angles of 0°-180° at intervals of 10° and compared with the calculation of treatment planning system(TPS) that pre-verified with ion chamber measuring.Results:Differences between the array detector and thimble chamber measurements were greater than 1% and 3.5% when the beam angle was larger than 30° and 60°,respectively.The measurements in the combined phantom were different from the calculation as high as 20% for 90° beam angle,2% at 90°± 5° and less than 1% for all the other beam angles.Conclusions:The 2D diode array is capable of being used in composite dose verification of IMRT when the beam angles of 90°± 5° and 270°± 5° are avoided.