THE ASSOCIATION OF HLA WITH BREAST CANCER AND ITS ER STATUS

摘要

Results of comparative study of Human Leu-cocytic Antigen (HLA-A), -B typing in 73 breast cancer (BC) patients having different estrogen receptor (ER) status and 50 healthy individuals in the northern part of China are reported. In 58 of the 73 patients, HLA-C, -DR typing were also studied in addition. The results of this study showed that HLA-Bw61 (40) were negatively associated with BC, while -Cw7 and -DRw6 were positively associated with BC. Moreover, -DR was more closely associated with ER(+) status with a RR value of 8.621. In the ER(-) group, there were no specific related antigens. In the light of the differences in pathology, prognosis and effect of endocrine therapy between ER(+) and ER(-) status, the authors are inclined to the view that the two kinds of breast cancer may be a heterogeneous disease.