Cancer Institute;
Chinese Academy of Medical Sciences;
Beijing;
Cancer Institute;
Chinese Academy of Medical Sciences;
Beijingerum spermidine was assayed by radioimmuno-assay in different stages of esophageal carcinogenesis in the population from high risk area of esophageal cancer;
Linxian County. The serum spermidine values were 76.94+74.38 ng ml in 36 normal individuals;
115.71+113.45 ng/ml in 35 patients with marked epithelial hyperplasia (MEH) and 294.48+135.36 ng/ml in 31 patients with early esophageal cancer. Patients with MEH were given intervention treatment by Aminoretinoic Ester or Anticancer B or placebo (starch) as controls. One year later;
samples from the population were collected again for serum spermidine msasurement. The values were 95.8+ 68.2 ng/ml in 27 normals;
125.1±72.9 ng/ml in 62 patients with MEH treated by Anticancer B;
125.6± 117.2 ng/ml in 64 patients with MEH treated by Aminoretinoic Ester;
162.4±76.6 ng/ml in 62 controls and 210.5±182.9 ng/ml in 44 patients with early esophageal cancer.The results showed that spermidine radioim-munoassay could reflect the tendency of esophageal precancerous changes toward cancer or back to normal. They can be taken as a mid-way monitor indicator for tumor-blocking drugs. Also;
it could be of value in the early diagnosis of esophageal cancer.;
esophageal; precancerous; carcinogenesis; placebo; starch; screening; Serum; tendency; marked; blocking;
