Department of Pathology;
Fourth Military Medical University;
Xi' an 710032;
Fox Chase Cancer Center;
PA 19111;
USA;
Fox Chase Cancer Center;
PA 19111;
USAhe specimens were from 110 patients with primary hepatic carcinoma. The formalin- fixed and paraffin-embedded sections were stained for HBxAg by ABC method and for HBsAg and HBcAg by PAP method. Of the 110 cases;
64 (58. 2%) showed HBxAg-positive reaction in tumor tissue;
and 63 (78. 8%) of 80 cases displayed positive HBxAg in surrounding non-cancerous hepatic tissue. Among the 64 cases with positive HBxAg in tumor tissue;
15 (23. 4%) were associated with HBsAg and/or HBcAg;
while in the 63 cases with positive HBxAg in non-tumor tissue;
45(71. 4%) were accompanied with HBsAg and/or HBcAg. These findings suggest a dose relationship between prlmay hepatic carcinoma and HBV infection. The high detection rate of HBxAg Indicates a very active expression of the Integrated HBV- DNA genome in the host cells. However;
the action of HBxAg in pathogenesis of hepatocellular carcinoma remains to be further investigated.;
Primary; hepatic; carcinoma; Hepatitis; B; X; antigen; Immunohistochemistry;