B16 melanoma cells were inoculated into theBALB/C mice to establish melanoma-bearing models.The antitumor effect of Tween-80 in combination withhyperthermia 41℃ was studied.We observed thechanges of the mortality of tumor-bearing mice,thetumor growth curves,activities of serum tumor necrosisfactor(STNF)and the lcvcl of scrum sialic acid(SSA)intumor-bearing mice.The number of pulmonarymetastatic tumor foci from blood flow was also detected.The results showed that combined with Tween-80,hyperthermia 41℃ could dramatically suppress thegrowrh of the melanoma in the feet of mice,survive thetumor-bearing mice and decrease the number of pulmonary metastatic tumor foci but no significant erffectswere observed by treatment with Tween-80 orhyperthermia at 41℃ alone.The activities of STNFand the level of SSA of the melanoma-bearing mice keptat higher levels than those of normal BALB/C mice.Tween-80 combined with heating 41℃ significantlydecreased activities of STNF,but the level of SSA stillkept high level
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