CATHEPSIN B EXPRESSION AND ITS RELATIONSHIP WITH MICROVESSEL DENSITY AND BIOLOGICAL BEHAVIOUR OF COLORECTAL CARCINOMA

摘要

Objective: To investigate cathepsin B(CB) expressionin colorectal carcinoma and its relationship withmicrovessel density (MVD) and biological behavior.Methods: CB and MVD were detected byimmunohistochemistry in 47 cases of colorectal carcinoma. Results: The expression of CB in mucinous colorectalcarcinoma was significantly higher than that inno-mucinous colorectal carcinoma. There was significantdifference (P<0.05). The MVD in group with positive CBwas stronger than that in group with negative CB. There was also significant difference (P<0.05). Conclusion: Theresults suggest that CB expression has correlation withMVD, invasion and metastasis in colorectal carcinoma,especially in mucinous colorectal carcinoma.