成纤维细胞直接重编程为心肌细胞研究进展

摘要

Cardiac regenerative therapy has attracted much attention as a novel approach for heart diseases.Direct reprogramming of fibroblasts into cardiomyocytes without going through a pluripotent stem cell stage would provide a promising source of cells for cell transplantation in future.This review summarizes the research methods and problems of direct reprogramming of fibroblasts into cardiomyocytes in vitro and in vivo,and forecasts the future development of this new strategy.%心肌细胞的再生疗法作为心脏疾病的新型疗法受到人们的广泛关注.细胞直接重编程技术为诱导获得心肌细胞提供了新的方法,它可以绕过多潜能的阶段,将一种终末分化的细胞直接重编程为心肌细胞,为将来细胞移植提供更为安全的细胞来源.文中对体内外直接重编程成纤维细胞为心肌细胞的研究方法及其存在的问题进行了总结,并对心肌细胞直接重编程的未来发展进行展望.