Fabrication and Properties of Poly(vinylalcohol)-glycosaminoglycantype I Collagen Composite Membrane as Tissue Regeneration Scaffolds

摘要

The objective of this paper is to design a porous polyvinyl alcohol (PVA) based on composite membrane with certain mechanical strength and biocompatibilities serving as tissue regenerative scaffolds. PVA-glycosaminoglycan (GAG)-type I collagen (COL) composite membrane was fabricated by PVA with different molecular weight (Mw) and alcoholysis degree (AD) being blended with certain amounts of GAG and COL and dried at 38℃for 24 h. The water content of the composite membranes were from 61.9%to 95.1%and swelling ratio ranged from 123.6%to 621.7%. Scanning electron micro-scope (SEM) analysis proved that PVA-GAG-COL composite membrane has porous and homogenous structure. Biocompatibility test results showed that the composite membrane was nontoxic, which could promote adhesion and proliferation of fibroblasts on the com-posite membrane. In conclusion, PVA-GAG-COL composite membrane with high water content and swelling ratio, suitable mechanical strength and good biocompatibility, has potential in tissue engineering and regenerative medicine.