天芪降糖胶囊联合二甲双胍对老年2型糖尿病伴脑微血管病变患者血液黏度、认知功能障碍的影响

摘要

目的 探讨天芪降糖胶囊联合二甲双胍对老年2型糖尿病伴脑微血管病变患者血液黏度、认知功能障碍的影响.方法 随机单双号将76例老年2型糖尿病伴脑微血管病变患者分为观察组与对照组,各38例.观察组予以天芪降糖胶囊联合二甲双胍治疗,对照组给予单纯二甲双胍治疗,比较2组临床疗效、不良反应情况,对2组治疗前后中医症候总积分、血糖、血脂、高敏C反应蛋白(hs-CRP)、血液流变学、简易精神状态检查量表(MMSE)总分测定.结果 观察组治疗总有效率89.47%,显著高于对照组的71.05%(P＜0.05);与治疗前比较,2组治疗后中医症候总积分、FPG、2 h PG、hs-CRP、TC、TG、LDL-C、全血高切黏度、全血低切黏度、血浆黏度、红细胞压积均显著降低,MMSE总分显著上升(P＜0.05),且观察组与对照组比较差异均有统计学意义(P＜0.05);2组均无明显不良反应发生.结论 天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变安全有效,能明显改善机体糖脂代谢及血液流变学,降低血液黏度,减轻认知功能障碍.%Objective To investigate the effect of Tianqi Jiangtang capsules combined with metformin on blood viscosity, cognitive disorder in elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions.Methods 76 patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions were divided into the observation group and the control group according to odd and even numbers, 38 cases in each group.The observation group were given Tianqi Jiangtang capsules combined with metformin while the control group were received metformin alone.The clinical curative effect, adverse reactions were compared between the two groups.The total score of TCM symptoms, blood glucose, blood lipid, high-sensitivity C reactive protein(hs-CRP), hemorheology and Mini Mental State Examination(MMSE)scores were determined before and after treatment.Results The total effective rate in the observation group(89.47%)was significantly higher than that in the control group(71.05%)(P< 0.05);After treatment, the total score of TCM symptoms, FPG, 2 h PG, hs-CRP, TC, TG, LDL-C, whole blood viscosity at high shear, whole blood viscosity at low shear, plasma viscosity and hematocrit were significantly lower than those before treatment, while MMSE scores were significantly higher(P< 0.05), and the above indexes in the observation group after treatment were significantly better than those in the control group(P< 0.05).There were no significant adverse reactions in the 2 groups.Conclusion Tianqi Jiangtang Capsules combined with metformin is safe and effective in the treatment of elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions.It can significantly improve lipid metabolism and hemorheology, reduce blood viscosity, and alleviate cognitive disorder.