丙氨酰谷氨酰胺强化肠外营养液对小儿化脓性阑尾炎 NO、IL-10、CRP及细菌移位率的影响

摘要

目的 探讨丙氨酰谷氨酰胺强化肠外营养液对小儿化脓性阑尾炎 NO、IL-10、CRP及细菌移位率的影响.方法 选取本院确诊为急性化脓性阑尾炎并发腹膜炎并进行手术治疗的患者72例,根据随机数字表法随机分为2组:实验组36例术后予常规抗生素及肠外营养支持;对照组36例术后予常规抗生素,予丙氨酰谷氨酰胺强化肠外营养液,连续治疗7天.观察2组患者治疗前后血清甲状腺激素、 NO、IL-10、CRP及细菌移位率的变化,探究丙氨酰谷氨酰胺的疗效机制及安全性.结果 与治疗前相比,治疗后2组患者血清中FT3、FT4含量较高(P<0.05),血清中CRP、NO及IL-10含量较低(P<0.05),血清中16Sr及BG 阳性率较低(P<0.05).与对照组比较,实验组血清中FT3、FT4含量较高(P<0.05),血清中CRP、NO及IL-10含量较低(P<0.05),血清中16Sr及BG 阳性率较低(P<0.05).结论 丙氨酰谷氨酰胺强化肠外营养液能够显著提高甲状腺激素水平,降低患者血清C-反应蛋白水平和细菌移位率, 并且其对患者所产生的不良反应较轻.%Objective To investigate the effect on NO、IL-10、CRP and bacterial translocation rate by glutamine enriched parenteral nutrition solution in purulent appendicitis in children.Methods72 cases of acute suppurative appendicitis complicated with peritonitis were selected and randomLy divided into control and treatment groups.Patients (36 cases) in the control group were given antibiotics and parenteral nutrition support for 7 days, 36 cases in the experiment group were given glutamine enriched parenteral nutrition solution for 7 days.NO、IL-10、 CRP and bacterial translocation rate were compared after the treatment.ResultsCompared with before treatment, two groups of patients with content of FT3, FT4 was higher(P<0.05), CRP, NO and IL-10、 content in serum was lower (P<0.05), 16Sr and BG positive rate was lower (P<0.05).Compared with the control group, the serum FT3, FT4 was higher(P<0.05), CRP, IL-8 and IL-6 content in serum was lower (P<0.05), 16Sr and BG positive rate was lower (P<0.05).ConclusionGlutamine enriched parenteral nutrition solution can significantly improve thyroid hormone levels,reduce serum CRP, bacterial translocation rate, and adverse reactions were mild.