盐酸羟考酮控释片治疗晚期癌症疼痛患者的临床疗效及安全性分析

摘要

目的 探讨盐酸羟考酮控释片治疗晚期癌症疼痛患者的临床疗效及安全性.方法 选取2014年5月~2016年5月宁夏回族自治区第五人民医院治疗的晚期癌痛患者130例,随机分为2组,每组各65例.对照组给予硫酸吗啡控释片治疗,观察组给予盐酸羟考酮控释片治疗,比较2组患者治疗后疗效、生活质量及不良反应.结果 治疗后,2组患者癌痛均有不同程度缓解,但观察组癌痛缓解总有效率较对照组更高(P<0.05).治疗后,2组患者生活质量均较治疗前有所提高(P<0.05),但观察组明显高于对照组(P<0.05).治疗期间2组患者均有不同程度的不良反应发生,且观察组不良反应发生率更低(P<0.05).结论 盐酸羟考酮控释片能显著改善晚期癌症疼痛患者疼痛情况,提升患者生活质量,不良反应发生率低.%Objective To investigate the clinical efficacy and safety of oxycodone hydrochloride controlled-release tablets in treatment of advanced cancer pain.Methods 130 patients with advanced cancer pain were selected and randomly divided into two groups,65 patients received oxycodone hydrochloride controlled-release tablets as observation group,65 patients received morphine sulfate controlled-release tablets as control group.Quality of life score was evaluated, clinical efficacy and safety were compared between two groups.Results After treatment, cancer pain of patients in two groups were relieved than pre-treatment (P<0.05), and patients in observation group were better than control group (P<0.05).After treatment, the quality of life in two groups were all improved ( P <0.05 ) , and patients in observation group was more obvious than control group ( P <0.05 ) .During the treatment, adverse reactions occurred in different degrees, and the incidence of adverse reactions in the observation group was lower than control group (P<0.05).Conclusion Oxycodone hydrochloride controlled-release tablets are effective drug in treatment of advanced cancer pain,which can significantly relieve pain and improve quality of life.