重组牛碱性成纤维细胞生长因子对牙龈炎患者的效果及对牙龈沟出血指数的影响

摘要

Objective To investigate the treatment effect of recombinant bovine basic fibroblast growth factor (rb-bFGF) in patients with gingivitis and its influence on gingival sulcus bleeding index. Methods Sixty-eight patients with gingivitis treated in our hospital were randomly divided into control group (34 cases) and observation group (34 cases). The control group were given basic periodontal therapy, while the observation group were treated with rb-bFGF. The clinical effects, gingival sulcus bleeding index (SBI) before and after treatment, and the recurrence were compared between the two groups. Results After treatment, the total effective rate (97.06%) of the observation group was significantly higher than that of the control group (70.59%), the difference was statistically significant (P<0.05). The SBI of the observation group was significantly lower than that of the control group at 1 and 2 weeks after treatment (P<0.05). The recurrence rate of the observation group (5.88%) was significantly lower than that of the control group (23.53%) (P<0.05). The incidence of complications such as pain, periodontal abscess, bromopnea and loosening was significantly lower in the observation group (8.82%) than in the control group (32.35%). The difference was statistically significant (P<0.05). Conclusion After rb-bFGF treatment, the symptoms of toothache and gingival swelling disappear, normal function of teeth is restored, gingival sulcus bleeding improves significantly, with fewer adverse reactions and obvious clinical effect.%目的 探讨牙龈炎患者应用重组牛碱性成纤维细胞生长因子(recombinant bovine basic fibroblast growth factor,rb-bFGF)治疗的效果及对其牙龈沟出血指数的影响.方法 选取68例牙龈炎患者,根据数字表法随机分为对照组和观察组,各34例,对照组患者给予牙周基础治疗,观察组患者则进行牙周基础联合rb-bFGF治疗.对比2组治疗的临床效果,治疗前后牙龈沟出血指数(sulcus bleeding index,SBI)的变化及复发情况.结果 治疗后,观察组患者的总有效率(97.06%)与对照组(70.59%)相比优势明显,差异具有统计学意义(P<0.05).治疗后1、2周,观察组患者SBI与对照组相比明显降低,差异具有统计学意义(P<0.05).观察组复发率(5.88%)明显低于对照组(23.53%),差异具有统计学意义(P<0.05).观察组患者疼痛、牙周脓肿、口臭及牙齿松动等并发症发生率(8.82%)明显少于对照组(32.35%),差异具有统计学意义(P<0.05).结论 牙龈炎患者采用rb-bFGF治疗后,牙痛、牙龈肿胀等不适症状基本消失,牙齿正常功能得以恢复,牙龈沟出血情况改善显著,不良反应少,临床效果显著.