生大黄保留灌肠对急性胰腺炎患者IL-6、 hs-CRP及血清内毒素的影响

摘要

Objective:To observe the clinical effect of Dahuang(Rhubarb) retention enema patients with severe acute pancreatitis and its influence on leukocyte interleukin6 (IL-6),High sentive C reactive protein (hs-CRP) and endotoxin.Methods:86 cases of acute pancreatitis were randomly divided into the control group(43 cases)and the treatment group(43 cases).The Control group was given saline enema and routine treatment of western medicine,while the treatment group was treated with Dahuang (Rhubarb)decoction retention enema and routine treatment,2 times/day.After 7 days of treatment,compare two groups of clinical curative effect.And compared before and after treatment between two groups in IL-6,hsCRP,endotoxin and amylase levels change.Results:Abdominal pain,abdominal distension,exhaust defecation,bowel sounds in treatment group patients were obviously improved.After treatment,the levels of serum IL-6,hs-CRP,endotoxin and amylase in the treatment group were significantly lower than those in the control group.Conclusion:Dahuang(Rhubarb)retention enema can significantly improve the clinical curative effect of severe acute pancreatitis,and its mechanism may be related to the inhibition of inflammatory reaction.%目的:观察生大黄保留灌肠对急性胰腺炎患者的临床疗效及对IL-6、hs-CRP和血清内毒素的影响.方法:将86例急性胰腺炎患者按随机数字表法分为对照组和治疗组各43例,对照组给予常规治疗及温盐水灌肠,治疗组给予常规治疗及生大黄保留灌肠,2组疗程均为7d,观察治疗前后2组临床指标的变化及白介素细胞-6(IL-6)、超敏C反应蛋白(hs-CRP)、血清内毒素及淀粉酶的变化.结果:治疗组患者腹痛、腹胀、排气排便、肠鸣音恢复等均显著改善,差异均有统计学意义.治疗后2组患者炎性指标水平均显著低于治疗前,2组比较治疗组血清IL-6、hs-CRP、血清内毒素和淀粉酶下降水平均优于对照组.结论:生大黄保留灌肠可明显提高急性胰腺炎临床疗效,其机制可能与抑制炎症反应有关.