During amplifying the new Frizzled receptor member of Wnt signling pathway in Schistosoma japonicum, a new gene which encoded a seven transmembrane protein containing 1141 amino acid which was only similar to Frizzled receptor family protein was obtained. The N terminal of SjSTMP also has a CRD structure, so it has the structural basis to act as a cell surface receptors. SjSTMP was regulated along with the development. There were differences in the levels of SjSTMP mRNA in different developmental stages and different genders, and these differences were also found in normal worms and dysplasia worms. The SjSTMP protein was widely distributed in almost all kinds of tissues of Schistosoma japonicum, and it had no tissue specificity. Further identification of the function of SjSTMP protein will be helpful to understand the developmental regulation of Schistosoma at molecular level.%本实验室在扩增血吸虫Wnt信号通路Frizzled受体家族新成员过程中,获得了一个新的七跨膜蛋白(Schistosoma japonicum seven transmembrane protein,SjSTMP)的编码基因,编码含有1141个氨基酸的蛋白质.SjSTMP蛋白仅与Frizzled蛋白具有相似性,有7个穿膜区,N端也具有半胱氨酸富集区,具有作为细胞表面受体的结构基础. SjSTMP的转录随发育调节,在不同发育阶段及不同性别间SjSTMP mRNA水平存在差异,在同一发育阶段的发育正常与发育不良虫体间SjSTMP mRNA水平也存在差异.SjSTMP蛋白在虫体组织内广泛分布,无组织特异性. SjSTMP蛋白功能的进一步确定,将有助于在分子水平了解血吸虫发育调控过程.
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