Vitamin-K2 dependent GGCX and MGP are required for homeostatic calci um regulation in epididymis

摘要

A low-calcium microenvironment is essential for spermatozoa to mature in the epididymis.Abnormal elevation of calcium concentration in the epididymal lumen will lead to premature sperm activation,decreased sperm motility,and even male fertility defects or infertility.However,the mechanism of the epididymal homeostastic calcium regulation has not been fully elucidated.