Investigating the correlation of Fgf signaling and Wnt signaling pathway with interuterine hyperglycemia-induced fetal lung heteroplasia

摘要

Pregnancy with diabetes mellitus(PGDM)has been known to affect the em br yonic development of various systems.No doubt that it has a negative impact on the respiratory system,but the specific pathogenesis is not clear.In this study,firstly we demonstrated that the fetuses had immature lung development in PGDM,including pulmonary epithelial cell decreased and fibrous tissue increased.Secondly,we show Fgf signaling and Wnt signal would be activated in PGDM.For further study,we used in vitro experiments showed that the transcription factor GATA6,lung epithelial related-factors gene was down-regulated in high glucose groups,and the expression of Wnt signal-related and Fgf signal-related gene were up-regulated in high glucose groups;Treated with high glucose and used the inhibitor of Wnt and Fgf signal,the expression of GATA6 and epithelial related-factors gene were up-regulated,while the expression of fibrosis-related genes was down-regulated.