Tanshinone IA decreases microcalcifications in plaque via Nox1-dependent reactive oxygen species generation of smooth muscle cells in apoE^(-/-) mice

摘要

A variety of NADPH oxidase(Nox)isoforms including Noxs 1,2,4 and 5 catalyze the formation of reactive oxygen species(ROS)in the vascular wall.The Noxl isoform complex in smooth muscle cells has received greater attention in the progression of atherogenesis in animal models.Thus,we explored the effect of traditional Chinese herbal medicine monomer tanshinone IIA on microcalcifications,and investigated the underlying molecular mechanism of ROS.The 8-week old maleapolipoprotein E-deficient(ApoE^(-/-))mice and C57BL/6 mice were divided into three groups:Control group(C57BL/6 mice),Model group(ApoE^(-/-) mice).