脱氧核糖核酸分子设计在电化学生物传感器中的应用

摘要

A new electrochemical biosensors based on the DNA configuration switch was represented in this review. Special DNA probes (stem-loop or aptamers etc. ) on the electrode surface dramatically change their configuration on the combination of target molecular giving birth to a detectable electro chemical signal. This strategy attracts extensive research interesting for its easier operation and less unspecific absorption, To this day, its analysis performance has been markedly developed with an expanding application. Here, we summarize the history of these sensors.%基于特殊DNA序列的构型变化的电化学生物传感器是一种高灵敏、高特异性的生物分析方法.固定在电极表面的特殊DNA探针(茎环、核酸适配体、四聚体等)因为目标物质的结合而发生构型变化,从而产生可检测的电化学信号,这种策略操作简便而且特异性强,引起了研究者的广泛关注.本文总结了目前基于基因构型变化的电化学生物传感器的发展历程.