电喷雾/光电离双源型小型离子阱质谱仪的研制

摘要

构建了一套电喷雾/紫外灯双电离源离子阱质谱仪系统,用于气体和液体样品的快速检测.仪器采用非连续大气压进样技术,通过夹管阀装置来同时完成电喷雾离子和中性气态样品的采集和传输.所配备的两种电离源适合不同的分析对象,在应用上具有一定的互补性,其中电喷雾源用于溶液中极性化合物的电离,而紫外电离源主要用于分析气态有机物.本研究选择了苯甲醚、甲苯、2,4-二甲基苯胺、精氨酸、利血平和阿斯巴甜等不同类型的样品,测试了仪器在使用不同电离模式下的工作性能.结果表明,电喷雾源和紫外光电离源可用于不同类型样品的电离,在分析2,4-二甲基苯胺时还能分别生成不同类型的分子离子.两种电离源在工作时互不干扰,既能单独使用,也能同时开启,可根据检测需求随意切换工作模式,获得更全面的样品成分信息.双离子源设计是扩展小型质谱仪应用范围的一种有效途径,这种方案不会明显增加仪器的体积,却能提供更多样化的分析功能,满足对不同类型样品的检测需求.%An electrospray/ultraviolet lamp dual-source ion trap mass spectrometer was developed for the rapid detection of gas and liquid samples.The instrument used the discontinuous atmospheric pressure sampling technique that both the electrospray ions and gaseous analytes were sampled and transferred using a pinch valve device.The two ionization sources were generally suitable for different kinds of analytes and provided complementary applications.Electrospray was used for the ionization of polar compounds in solution, while the UV ionization source was mainly applied for the analysis of gaseous organic compounds.A variety of samples such as anisole, toluene, 2,4-dimethylaniline, arginine, reserpine and aspartame were employed to test the performance in different working mode of the instrument.The results showed that the two sources were feasible for ionization of different types of samples, and different types of molecular ions could be generated when 2,4-dimethylaniline was analyzed.The two ionization sources could be used alternately or simultaneously without interference, and the working mode was also switched to fit the application requirements.The dual-source configuration was an effective way to extend the applications for miniature mass spectrometers.It did not significantly increase the size of the instrument, but provided more versatile analysis to meet the need for the measurement of different types of samples.