Objective To elucidate the diagnosis, differential diagnosis and treatment of Kimura. Methods Have 3 cases with Kimura take Pathological examination and observe their clinical and pathological characteristics. Perform Immunohisto-chemical staining using CD45 , CD20 , CD79a, CD3 , CD45RO. Results Of 3 cases ( all males ) two cases had Kimura located on the head and neck, the other on the back, manifested as solitary or multiple subcutanenous nodules. There were morphological features: florid hyperplasia of lymphoid tissue, lymphoid follicles, proliferation of post - capillary venules between follicles, large number of eosinophils aggregated and microabscesses formed. Immunohistochemical study showed CD20, CD79a in lymphoid follicles and CD3, CD45RO in interfollicular antigen. Conclusion Kimura is a rare and unclear disease in clinic. The exact diagnosis depends on histopathological examination. It can be treated with local excision of lesion of operation and radiotherapy and steroid therapy after operation.%目的 分析Kimura病的病理特点,探讨其诊断、鉴别诊断及治疗方法.方法 3例Kimura患者行病理检查,观察其病理特点,采用CD45、CD20、CD79a、CD3、CD45RO进行免疫组化染色.结果 3例Kimura患者均为男性,其中2例发生于头颈部,1例发生于背部软组织;表现为皮下单发或多发的小结节.镜下均以淋巴组织增生为主,淋巴滤泡形成;滤泡间见增生的毛细血管后微静脉样小血管,大量嗜酸粒细胞浸润,局灶可见嗜酸性小脓肿形成.免疫组化染色显示,淋巴滤泡表达CD20、CD79a,滤泡间组织多表达CD3、CD45RO.结论 Kimura病是一种原因不明的罕见疾病,通过病理检查确诊,可行局部手术切除病变,术后进行放疗、糖皮质激素或化疗等治疗.
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