苦碟子联合阿托伐他汀对不稳定型心绞痛患者血脂影响研究

摘要

Objective To investigate and analyze the effect of Ixeris Sonchifolia Hance injection combined with Atorv-astatin on lipid metabolism in patients with unstable angina pectoris. Methods 200 patients with unstable angina were randomly divided into two groups with 102 in trial group and 98 in control group. Patients in trial group were treated with Ixeris Sonchifolia Hance injection 40 ml by intravenous infusion once a day in addition to Atorvastatin therapy, and patients in control group were only treated with Atorvastatin therapy for unstable angina, for two weeks as a course. The changes in levels of plasma triglyceride ( TG ), total cholesterol ( TC ), high - density lipoprotein cholesterol ( HDL - C ) and Low - density lipoprotein cholesterol ( LDL - C ) were measured in both groups before and after treatment; and hemorheological parameters were determined. Results ( 1 ) Comparison of lipid Change: in the trial group: the blood levels of TC, TG and LDL - C were decreased, there is statistical significance ( P ＜ 0. 05 ); HDL - C were increased ( P ＜ 0. 05 ). In the control group: the blood levels of TC and LDL -C were decreased ( P ＜0. 05 ); HDL - C were increased ( P ＜0. 05 ). After treatment, the differences between the two groups of these indicators were statistically significant (P＜0. 05). (2) Comparison of hemorheological parameters: compared with before treatment, two groups of whole blood viscosity plasma viscosity decreased ( P ＜ 0. 05 ); treatment between the two groups showed: more significant changes in the trial group, the difference was statistically significant ( P ＜0. 05 ). Conclusion Ixeris Sonchifolia Hance injection is effective lipid -lowering, better than Atorvastatin therapy alone.%目的 观察苦碟子注射液联合阿托伐他汀对不稳定型心绞痛患者血脂的影响.方法 选取辽宁医学院附属第一医院2009年5月-2010年5月心内科住院的200例不稳定型心绞痛患者为研究对象,随机分为对照组98例和治疗组102例.对照组给予阿托伐他汀调脂、阿司匹林及硝酸酯类等常规治疗,治疗组在阿托伐他汀治疗基础上给予10%葡萄糖注射液150 ml(或09%氯化钠注射液150 ml)加苦碟子注射液40 ml静脉滴注,1次/d,疗程为14 d.两组均于治疗前后测定血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,并测定血液流变学指标.结果 (1)血脂比较:治疗组TC、TG、LDL-C水平较治疗前明显下降(P＜0.05＝;HDL-C水平较治疗前明显升高(P＜0.05＝.对照组TC、LDL-C水平较治疗前明显下降(P＜0.05＝,HDL-C水平较治疗前明显升高(P＜0.05＝.治疗后两组以上指标间差异均有统计学意义(P＜0.05＝.(2)血液流变学比较:与治疗前比较,两组全血比黏度、血浆比黏度均明显降低(P＜0.05＝;治疗后两组全血比黏度、血浆比黏度差异均有统计学意义(P＜0.05).结论 苦碟子联合阿托伐他汀治疗不稳定型心绞痛,降脂效果优于单独阿托伐他汀治疗.