Objective To investigate the correlation of serum high sensitive C - reactive protein ( hs - CRP ) and N -terminal pro - brain natriuretic peptide ( NT - proBNP ) levels and estimated glomerular filtration rate ( eGFR ) with the severity of angiographic coronary artery disease. Methods A total of 103 patients who had undergone coronary angiography were enrolled in this study. They were divided into four groups based on the severity of cardiovascular disease: control group ( n = 15 ), single - vessel disease group ( n = 38 ), two - vessel disease group ( n = 25 ), and three - vessel disease group ( n = 25 ). The serum concentrations of hs - CRP and NT - proBNP were determined and the eGFR was calculated in the four groups. Results Serum hs - CRP and NT - proBNP levels were significantly higher and eGFR significantly lower in groups with severer diseases ( P < 0. 01 ). Conclusion The serum hs - CRP and NT - proBNP levels and eGFR can be used for assessing the severity of coronary artery disease.%目的 探讨冠心病患者超敏C-反应蛋白(hs-CRP)、氨基末端B型脑钠肽前体(NT-proBNP)和估算肾小球滤过率(eGFR)与不同冠状动脉病变程度的关系.方法 选择103例经冠状动脉造影检查的患者,根据冠状动脉病变的程度分为对照组(15例)、单支组(38例)、双支组(25例)、三支组(25例).测定各组血清hs-CRP、NT-proBNP水平,并计算出eGFR.结果 随着冠状动脉病变程度加重,对照组、单支组、双支组、三支组血清NT-proBNP、hs-CRP水平越高,eGFR越低,组间比较差异均有统计学意义(P＜0.01).结论 hs-CRP、NT-proBNP和eGFR水平可指导评估冠状动脉病变严重程度.
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