Objective To investigate correlation of the severity of illness with the levels of serum alanine aminotrans-ferase ( ALT) and aspartate aminotransferase ( AST ) in patients with H1N1 influenza A virus infection so as to provide an evidence for assessing severity of illness clinically. Methods Totally 206 patients with A/H1N1 influenza from September to December 2009 were recruited and divided as mild, severe and critical groups according to the treatment scheme of A/H1N1 influenza. Their results of serum ALT, AST, creatine kinase ( CK ) and CK - MB was analyzed. Results Among the 3 groups the abnormal proportions of AST, ALT showed a significant difference ( P < 0. 01 ) .The ALT value of ( 144. 0 ± 81. 1 ) U/L in the critical group was higher than ( 27. 6 ±2. 8 ) U/L in the severity group and ( 24. 4 ± 1. 2 ) U/L in the mild group ( P <0. 01 ) . And the AST value of ( 355. 8 ± 229. 6 ) U/L in the critical group was higher than ( 64. 2 ± 8. 5 ) U/L in the severity group and ( 34. 1 ±1.2) U/L in the mild group ( P <0. 01 ) . The Spearman correlation analysis revealed that the severity of patients with A H1N1 influenza was positively correlated with AST and ALT levels ( r = 0. 265, 0. 479, P = 0. 000 ) . Conclusion The higher levels of serum ALT, AST of the patients with A/H1N1 influenza are the efficacious indices for judgment of the severity of illness.%目的 探讨甲型H1N1流感患者血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平与疾病严重程度的关系,为临床判断甲型H1N1流感患者轻重程度提供依据.方法 分析2009年9-12月收治的206例甲型H1N1流感患者的AST、ALT以及肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)检验结果,依据<甲型H1N1流感诊疗方案(2009年第三版)>将患者分为轻症组、重症组、危重症组,对各组AST、ALT结果进行统计学分析.结果 三组患者AST、ALT异常率间差异有统计学意义(P＜0.01).危重症组血清ALT(144.0±81.1)U/L高于重症组(27.6±2.8)U/L及轻症组(24.4±1.2)U/L,差异均有统计学意义(P＜0.01).危重症组AST(355.8±229.6)U/L高于重症组(64.2±8.5)U/L与轻症组(34.1±1.2)U/L,差异均有统计学意义(P＜0.01).Spearman相关分析显示,甲型H1N1流感患者危重程度与血清ALT、AST水平呈正相关(r=0.265、0.479,P=0.000).结论 甲型H1N1流感病毒感染后患者血清ALT、AST水平升高,ALT、AST是判断甲型H1N1流感患者疾病严重程度的有效指标.
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