琥珀酸美托洛尔缓释片控制老老年持续性房颤心室率临床研究

摘要

目的：探讨琥珀酸美托洛尔缓释片控制老老年持续性房颤的疗效及安全性.方法：将49例持续性房颤患者随机分为观察组(24例)和对照组(25例)，观察组在常规治疗基础上使用琥珀酸美托洛尔缓释片，对照组在常规治疗基础上采用小剂量地高辛.治疗4周后，观察两组治疗前后静息心室率、运动心室率变化.结果：两组患者的静息心室率治疗后比治疗前均明显降低(P<0.05)；运动心室率观察组治疗后比治疗前明显降低(P<0.01)，对照组治疗前后变化不显著(P>0.05)，治疗后观察组运动心室率比对照组明显低(P<0.01)；观察组总有效率为91.7%，明显高于对照组的84.0%(P<0.05).结论：琥珀酸美托洛尔缓释片能有效控制老老年房颤患者的心室率，达到治疗的目的.%　　Objective:Toinvestigatetheefficacyandsafetyofmetoprololsuccinatesustained-releasetabletsincontrollingtheveryagedpatientsventricularrateofpersistentatrialfibrillation.Methods:49casesofpatientswithpersistentatrialfibrillationwererandomlydivideintotwogroups.Theobservationgroupwas24cases.Thecontrolgroupwas25cases.Bothgroupsweregiventhebasisofconventionaltherapy.Theobservationgroupusedmetoprololsuccinatesustained-releasetablets.Thecontrolgroupusessmalldosesofdigoxin.Afterfourweekstreatment,changesofrestingheartandheartrateafterexerciseratewereobservedbeforeandaftertreatment.Results:Therestingheartrateoftwogroupspatientspost-treatmentwassignificantlylowerthanpretherapy(P<0.05).Theobservationgroupofheartrateafterexercisepost-treatmentwassignificantlylowerthanpretherapy(P<0.01),butthecontrolgroupdidnotchangesignificantlybeforeandaftertreatment(P>0.05).Theobservationgroupofheartrateafterexercisepost-treatmentwassignificantlylowerthanthecontrolgroup(P<0.01).Thetotaleffectiveofobservationgroup(91.7%)wassignificantlyhigherthancontrolgroup(84.0%).Conclusion:Metoprololsuccinatesustained-releasetabletscaneffectivelycontroltheelderlypatients’sventricularrateofpersistentatrialfibrillation,andachievetherapeuticpurposes.