综合干预措施对HIV/AIDS孕妇母婴阻断107例的临床分析

摘要

目的：探讨采用综合措施阻断HIV/AIDS母婴垂直传播的效果.方法：选取2005年1月-2010年12月在笔者所在医院接受综合措施母婴阻断的HIV阳性孕妇107例为研究组，同期在广州市某医院产科的HIV阴性孕妇135例作为对照组.研究组采用HAART、剖宫产及新生儿出生时给予抗病毒药、人工喂养等综合措施进行母婴阻断，监测两组孕妇产前的肝功能、血常规、生化指标.研究组新生儿出生时及18个月龄时进行HIV检测.结果：研究组的107例新生儿出生时及18个月龄时检测HIV抗体均呈阴性.研究组孕妇白细胞、红细胞、血色素、球蛋白、空腹血糖与对照组比较，差异有统计学意义(P<0.05)；两组血小板、甘油三酯、总胆固醇等指标比较差异无统计学意义(P>0.05).结论：采取孕产期前综合阻断措施，能有效降低HIV母婴垂直传播的发生率.%Objective:To investigate the influence of combinative treatment for blockade of HIV mother-to-child transmission on HIV-infected pregnant patients.Methods:107 pregnant women identified with HIV infected were given combinative treatment for blockade of HIV mother-to-child transmission from Jan 2005 to Dec 2010.Their newborn babies were given anti-viral drug and artificial feeding.135 HIV negative pregnant women were chosen at random in a hospital of Guangzhou city as control group.Results:All the newborns babies were negative to HIV-Ab (ELISA) at the moment they were born and after 18 months.The WBC,RBC,Hb,and GLB were statistic significant differences between study group and control group(P<0.05),while the hemoglobin,albumin,glucose,total cholesterol,triglyceride were no significant differences between them(P>0.05).Conclusion:Combinative treatment could be effective to blockade of HIV mother-to-child transmission.