反复肺炎患儿机体免疫功能变化的研究分析

摘要

目的：通过检测反复肺炎患儿免疫球蛋白、T细胞亚群的变化，探讨免疫功能检测在反复肺炎中可能的作用。方法：分别采用散射速率比浊法及流式细胞仪，检测各组儿童血清免疫球蛋白及T细胞亚群的指标变化。结果：反复肺炎患儿IgG、IgA含量均显著低于对照组儿童(P<0.01)，而两组IgM含量比较差异无统计学意义(P>0.05)；反复肺炎患儿T淋巴细胞亚群CD4+的百分含量及CD4+/CD8+比值均明显低于对照组儿童(P<0.01)，而CD8+的百分含量则高于对照组儿童(P<0.01)。结论：反复肺炎患儿存在体液免疫、细胞免疫功能紊乱，这可能是患儿肺炎反复发作和病程迁延不愈的原因之一。%Objective:To investigate the changes in serum Immunoglobulins and T lymphocyte subgroup in children with recurrent pneumonia,and the role of immune function testing in recurrent pneumonia.Method:The expressions of Immunoglobulin and T lymphocyte subgroup were detected by rapid immune turbidimetry and flow cytometry in recurrent pneumonia children and healthy children(Control group).Result:The levels of IgG,IgA were all significantly lower in recurrent pneumonia children than those of control group(P<0.01),there were no significant differences in the levels of IgM between two groups(P>0.05).Meanwhile the percentage of CD4+cell and the ratio of CD4+/CD8+were also all significantly lower in recurrent pneumonia children than those of control group(P<0.01),but the percentage of CD8+cell was significantly higher in recurrent pneumonia children than those of control group(P<0.01).Conclusion:There are disfunctions of cellular immunity and humoral immunity in recurrent pneumonia children,which may contribute to the pathogenesis in children with recurrent pneumonia.