血浆FIB、FDP和D-二聚体水平监测在慢性阻塞性肺疾病患者中的意义

摘要

Objective:To explore the monitoring significance of the plasma fibrinogen(FIB),fibrinogen/fibrin degradation products(FDP) and D dimer(D-D) levels in patients with chronic obstructive pulmonary disease.Methods:50 cases of patients with chronic obstructive pulmonary disease from May 2013 to May 2014 treated were as the observation group.50 cases of healthy subjects were selected as the control group.Results:The plasma FIB,FDP and D-dimer levels of the observation group were higher than that of the control group,and the differences has statistical significance(P<0.05).The plasma FIB,FDP and D-dimer levels in acute group with chronic obstructive pulmonary disease were higher than that of the stable group,and the differences were statistically significant(P<0.05).The D-dimer levels of the stable group increased more significantly compared with the control group(P<0.01),the plasma FIB,FDP levels increased slightly(P<0.05).Conclusion:Monitoring the plasma fibrinogen(FIB), fibrinogen/fibrin degradation products(FDP) and D dimer (D-D) levels of the patients with chronic obstructive pulmonary disease could grasp the fibrinolytic activity of the patient's body to guide clinical treatment better.%目的：探讨血浆纤维蛋白原(FIB)、纤维蛋白原/纤维蛋白降解产物(FDP)和D-二聚体水平监测在慢性阻塞性肺疾病患者中的意义。方法：2013年5月-2014年5月收治慢性阻塞性肺疾病患者50例作为观察组，选择50例健康者作为对照组。结果：观察组血浆FIB、FDP和D-二聚体水平均高于对照组，差异均有统计学意义(P＜0.05)。慢性阻塞性肺疾病急性加重组的血浆FIB、FDP和D-二聚体水平均高于稳定组，差异均有统计学意义(P＜0.05)。稳定组D-二聚体水平与对照组比较显著上升(P＜0.01)，血浆FIB、FDP轻度上升(P＜0.05)。结论：通过监测慢性阻塞性肺疾病患者的血浆纤维蛋白原(FIB)、纤维蛋白原/纤维蛋白降解产物(FDP)和D-二聚体水平，掌握患者体内的纤溶活性情况，从而更好地指导临床治疗。