维持抗抑郁药治疗抑郁症复发或复发的预防有效性和成本效益比较

摘要

目的：观察正念认知疗法与维持减少或中断抗抑郁治疗对于抑郁症复发或复发的预防有效性和成本效益。方法：收治先前发生抑郁症事件≥3次及维持性抗抑郁治疗剂量患者400例，随机平分为 MBCT-TS 组或维持抗抑郁组，观察两组抑郁症复发时间或复发次数，24个月内对患者随访5次。结果：两组复发时间或复发次数差异无统计学意义(P＞0.05)，严重不良反应数亦然。结论：对于预防抑郁症复发，MBCT-TS并不优于维持抗抑郁治疗，两种治疗对于抑郁症复发或反复、残留症状和生活质量均产生积极的影响。%Objective:To observe the effectiveness and cost effectiveness of mindfulness based cognitive therapy,and maintain the reduction or interruption of antidepressant treatment for depression relapse or recurrence prevention.Methods:400 patients with depression occurred≥3 times and received maintenance dose of antidepression therapy were selected.They were randomly divided into the MBCT-TS group and the maintenance of antidepressant treatment group.The time of relapse and recurrence of depression were observed.Patients were followed up for 5 times during 24 months.Results:There was no significant difference between groups in the time of recurrence or the frequency of recurrence(P>0.05),and the number of serious adverse reactions was also the same.Conclusion:For preventing the recurrence of depression,MBCT-TS is not superior to maintenance of antidepressant treatment,and these two types of treatment have a positive impact on the recurrence or relapse of depression,residual symptoms and quality of life.