神经纤毛蛋白（ NRP ）⁃1作为NRP家族中重要成员之一，常表达于内皮细胞及部分肿瘤细胞。近年来越来越多研究证实NRP⁃1主要通过VEGF⁃VEGFR2通路在肿瘤发生发展中起重要作用。除此之外，NRP⁃1还可以与其他生长因子及其受体结合，如血小板衍生生长因子（ PDGF）及其受体。另外，最近有研究表明NRP⁃1通过NRP⁃1⁃ABL通路促进血管形成，而不依赖VEGF⁃VEGFR2。并且NRP⁃1⁃ABL和PDGF通路下游都涉及Rad51蛋白，而Rad51蛋白则是体内催化同源重组性DNA修复最主要的关键酶。 Rad51过表达可使肿瘤细胞对放化疗产生耐受。抑制NRP⁃1也许可以弥补单纯抑制VEGF⁃VEGFR2通路在肿瘤治疗中的不足，为肿瘤的治疗提供新思路。因此本文就NRP⁃1不依赖VEGF⁃VEGFR2通路在肿瘤发生发展中的作用作一综述。%Neuropilin⁃1 ( NRP⁃1) , an important member of NRP family, is often expressed in endothelial cells and some cancer cells. Recent studies suggest that NRP⁃1 promotes tumor development mainly via VEGF⁃VEGFR2 pathway. In addition, NRP⁃1 also binds with other growth factors such as platelet derived growth factor ( PDGF) and its receptors. Moreover, recent studies show that NRP⁃1 promotes angiogenesis via NRP⁃1⁃ABL pathway, but independent of VEGF⁃VEGFR2. Downstream of NRP⁃1⁃ABL, PDGF sig⁃naling, is related to RAD51 protein, the key enzyme that catalyzes homologous recombination of DNA repair. Overexpression of RAD51 induces cancer cell resistance to radiotherapy and chemotherapy. Inhibition of NRP⁃1 may overcome the limitations of individual inhibi⁃tion of VEGF⁃VEGFR2 pathway in cancer therapy, and provide new ideas for cancer treatment. Therefore, we review the role of NRP⁃1 in tumorigenesis and development independent of VEGF⁃VEGFR2 pathway.
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