Synthesis, Structure Analysis, and Antitumor Activity of (R)-2,4-Dioxo-5-fluoro-1-1-(methoxycarbonyl) Ethylaminocar bonylmethyl-1,2,3,4-tetrahydropyrimidine

摘要

A new dipeptide compound, (R)-2,4-dioxo-5-fluoro-1-[1-(methoxycarbonyl) ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine (5-FUAPM), has been synthesized and identified by means of elemental analysis, IR, 1H NMR and 13C NMR spectra.The single crystal of compound 5-FUARM·DMF was also obtalend and characterized by DSC-TGA techniques. The crystal belongs to orthorhombic space group P212121 with the cell parameters: a=0.4740(7) nm, b= 1.923(3) nm, c= 1.9229 nm, a=β=γ=90°, V= 1.753 nm3, Z=4, Dc=1.312 g/cm3, Mr=346.32,F(000)=728 andμ=0.111 mm-1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5-FUAPM has certain antitumor activities.