Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy

摘要

We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugsconjugated polydopamine nanoparticles(PDOXCBs),which integrated near infrared(NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle.Upon a mild NIR irradiation(808 nm,1 W/cm^(2),10 min),PDOXCBs gradually heated aqueous solution over 12.8-13.9℃,which accordingly enhanced in vitro dual doxorubicin(DOX) and chlorambucil(CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol(DTT).The combination photothermal-cocktail chemotherapy(PTT-CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration(IC_(50)) of 2.23 μg/mL and a combination index of0.36,displaying a superior synergistic effect between PTT and CCT in vitro.