Asymmetric synthesis of pyrrolo1,2-aindoles via organocatalytic3+2annulation of substituted 2-vinylindoles with azlactones

摘要

The chiral phosphoric acid catalyzed asymmetric[3+2]annulation of substituted 2-vinylindoles with azlactones has been established.This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo[1,2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions.