Friedel-Crafts trifluoromethylthiolation of electron-rich(hetero)arenes with trifluoromethylthio-saccharin in 2,2,2-trifluoroethanol(TFE)

摘要

A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2,2,2-trifluoroethanol(TFE) as the solvent was described.The reactions were conducted at 40℃and a variety of common functional groups were compatible.